Cargando…

The Nucleotide Exchange Factor Ric-8A Is a Chaperone for the Conformationally Dynamic Nucleotide-Free State of Gαi1

Heterotrimeric G protein α subunits are activated upon exchange of GDP for GTP at the nucleotide binding site of Gα, catalyzed by guanine nucleotide exchange factors (GEFs). In addition to transmembrane G protein-coupled receptors (GPCRs), which act on G protein heterotrimers, members of the family...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomas, Celestine J., Briknarová, Klára, Hilmer, Jonathan K., Movahed, Navid, Bothner, Brian, Sumida, John P., Tall, Gregory G., Sprang, Stephen R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154933/ https://www.ncbi.nlm.nih.gov/pubmed/21853086 http://dx.doi.org/10.1371/journal.pone.0023197

Ejemplares similares

Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα
por: Kant, Ravi, et al.
Publicado: (2016)

Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
por: McClelland, Levi J., et al.
Publicado: (2020)

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor
por: Srivastava, Dhiraj, et al.
Publicado: (2019)

The G protein alpha Chaperone and Guanine-Nucleotide Exchange Factor RIC-8 Regulates Cilia Morphogenesis in Caenorhabditis elegans Sensory Neurons
por: Campagna, Christina M., et al.
Publicado: (2023)

The G protein alpha chaperone and guanine-nucleotide exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons
por: Campagna, Christina M., et al.
Publicado: (2023)

Ric-8A, a Gα Protein Guanine Nucleotide Exchange Factor Potentiates Taste Receptor Signaling
por: Fenech, Claire, et al.
Publicado: (2009)

The Guanine Nucleotide Exchange Factor RIC8 Regulates Conidial Germination through Gα Proteins in Neurospora crassa
por: Eaton, Carla J., et al.
Publicado: (2012)

Correction: The Guanine Nucleotide Exchange Factor RIC8 Regulates Conidial Germination through Gα Proteins in Neurospora crassa
por: Eaton, Carla J., et al.
Publicado: (2013)

The nucleotide exchange factors of Hsp70 molecular chaperones
por: Bracher, Andreas, et al.
Publicado: (2015)

Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis
por: Saare, Merly, et al.
Publicado: (2015)

MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
por: Yan, Yahui, et al.
Publicado: (2019)

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone
por: Konovalova, Svetlana, et al.
Publicado: (2018)

The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a)
por: Kerchner, Keshia M., et al.
Publicado: (2021)

Chemical Chaperones Exceed the Chaperone Effects of RIC-3 in Promoting Assembly of Functional α7 AChRs
por: Kuryatov, Alexander, et al.
Publicado: (2013)

Activation of G Proteins by Guanine Nucleotide Exchange Factors Relies on GTPase Activity
por: Stanley, Rob J., et al.
Publicado: (2016)

An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP
por: Siegenthaler, Kevin D, et al.
Publicado: (2017)

Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors
por: Do, Hoa Quynh, et al.
Publicado: (2023)

Pyrrolidine nucleotide analogs with a tunable conformation
por: Poštová Slavětínská, Lenka, et al.
Publicado: (2014)

Fe protein docking transduces conformational changes to MoFe nitrogenase active site in a nucleotide-dependent manner
por: Tokmina-Lukaszewska, Monika, et al.
Publicado: (2023)

Universal buffers for use in biochemistry and biophysical experiments
por: Brooke, Dewey, et al.
Publicado: (2015)

Substrate binding by the yeast Hsp110 nucleotide exchange factor and molecular chaperone Sse1 is not obligate for its biological activities
por: Garcia, Veronica M., et al.
Publicado: (2017)

Nucleotide Binding by Lhs1p Is Essential for Its Nucleotide Exchange Activity and for Function in Vivo
por: de Keyzer, Jeanine, et al.
Publicado: (2009)

The Importance of Mg(2+)‐Free State in Nucleotide Exchange of Oncogenic K‐Ras Mutants
por: Pálfy, Gyula, et al.
Publicado: (2022)

Neuroinflammation Modulation via α7 Nicotinic Acetylcholine Receptor and Its Chaperone, RIC-3
por: Mizrachi, Tehila, et al.
Publicado: (2021)

The Tomato Nucleotide-binding Leucine-rich Repeat Immune Receptor I-2 Couples DNA-binding to Nucleotide-binding Domain Nucleotide Exchange
por: Fenyk, Stepan, et al.
Publicado: (2016)

In Vivo Importance of Actin Nucleotide Exchange Catalyzed by Profilin
por: Wolven, Amy K., et al.
Publicado: (2000)

The many faces of the guanine-nucleotide exchange factor trio
por: van Rijssel, Jos, et al.
Publicado: (2012)

Nucleotide exchange is sufficient for Hsp90 functions in vivo
por: Reidy, Michael, et al.
Publicado: (2023)

Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs
por: Zavialov, Andrey V, et al.
Publicado: (2005)

Ligand binding and conformational dynamics of the E. coli nicotinamide nucleotide transhydrogenase revealed by hydrogen/deuterium exchange mass spectrometry
por: Zöller, Jonathan, et al.
Publicado: (2022)

Speculation on How RIC-3 and Other Chaperones Facilitate α7 Nicotinic Receptor Folding and Assembly
por: Loring, Ralph H.
Publicado: (2022)

The structural switch of nucleotide-free kinesin
por: Cao, Luyan, et al.
Publicado: (2017)

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR
por: Csanády, László, et al.
Publicado: (2013)

Computational and NMR spectroscopy insights into the conformation of cyclic di-nucleotides
por: Wang, Baifan, et al.
Publicado: (2017)

Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin
por: Toti, Kiran S., et al.
Publicado: (2022)

Nucleotide binding is the critical regulator of ABCG2 conformational transitions
por: Gyöngy, Zsuzsanna, et al.
Publicado: (2023)

Dynamic coupling between conformations and nucleotide states in DNA gyrase
por: Basu, Aakash, et al.
Publicado: (2018)

Ras Conformational Switching: Simulating Nucleotide-Dependent Conformational Transitions with Accelerated Molecular Dynamics
por: Grant, Barry J., et al.
Publicado: (2009)

Formation of a stable RNase Y-RicT (YaaT) complex requires RicA (YmcA) and RicF (YlbF)
por: Dubnau, Eugenie, et al.
Publicado: (2023)

Formation of a stable RNase Y-RicT (YaaT) complex requires RicA (YmcA) and RicF (YlbF)
por: Dubnau, Eugenie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6nsck2llq3lbjq14u2q6k4f3r5