Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

Phosphoinositide 3-kinase δ is upregulated in lymphocytic leukemias. Because the p85-regulatory subunit binds to any class IA subunit, it was assumed there is a single universal p85-mediated regulatory mechanism; however, we find isozyme-specific inhibition by p85α. Using deuterium exchange mass spe...

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Detalles Bibliográficos
Autores principales: Burke, John E., Vadas, Oscar, Berndt, Alex, Finegan, Tara, Perisic, Olga, Williams, Roger L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155019/
https://www.ncbi.nlm.nih.gov/pubmed/21827948
http://dx.doi.org/10.1016/j.str.2011.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155019/
https://www.ncbi.nlm.nih.gov/pubmed/21827948
http://dx.doi.org/10.1016/j.str.2011.06.003

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