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Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

Phosphoinositide 3-kinase δ is upregulated in lymphocytic leukemias. Because the p85-regulatory subunit binds to any class IA subunit, it was assumed there is a single universal p85-mediated regulatory mechanism; however, we find isozyme-specific inhibition by p85α. Using deuterium exchange mass spe...

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Detalles Bibliográficos
Autores principales:	Burke, John E., Vadas, Oscar, Berndt, Alex, Finegan, Tara, Perisic, Olga, Williams, Roger L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155019/ https://www.ncbi.nlm.nih.gov/pubmed/21827948 http://dx.doi.org/10.1016/j.str.2011.06.003

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