Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function

HD (Huntington's disease) is characterized by dysfunction and death of striatal MSNs (medium-sized spiny neurons). Excitotoxicity, transcriptional dysregulation and mitochondrial abnormalities are among the mechanisms that are proposed to play roles in HD pathogenesis. To determine the extent o...

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Detalles Bibliográficos
Autores principales: Ho Kim, Soong, Thomas, Carlos A, André, Véronique M, Cummings, Damian M, Cepeda, Carlos, Levine, Michael S, Ehrlich, Michelle E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Neurochemistry 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155197/
https://www.ncbi.nlm.nih.gov/pubmed/21542802
http://dx.doi.org/10.1042/AN20110009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155197/
https://www.ncbi.nlm.nih.gov/pubmed/21542802
http://dx.doi.org/10.1042/AN20110009

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