The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma

It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. Depleting arginine using pegylated arginine deiminase (ADI-PEG20) results in cell death in melanoma but not normal cells. This concept was translat...

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Detalles Bibliográficos
Autores principales: Savaraj, Niramol, Wu, Chunjing, Kuo, Marcus Tien, You, Min, Wangpaichitr, Medhi, Robles, Carlos, Spector, Seth, Feun, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155228/
https://www.ncbi.nlm.nih.gov/pubmed/21901069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155228/
https://www.ncbi.nlm.nih.gov/pubmed/21901069

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