In vitro and in vivo pre-clinical analysis of a F(ab')(2 )fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers

BACKGROUND: The objective of this study was to characterize the in vitro and in vivo properties of the F(ab')(2 )fragment of panitumumab and to investigate its potential for imaging and radioimmunotherapy. METHODS: The panitumumab F(ab')(2 )was generated by enzymatic pepsin digestion. Afte...

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Detalles Bibliográficos
Autores principales: Wong, Karen J, Baidoo, Kwamena E, Nayak, Tapan K, Garmestani, Kayhan, Brechbiel, Martin W, Milenic, Diane E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155408/
https://www.ncbi.nlm.nih.gov/pubmed/21845232
http://dx.doi.org/10.1186/2191-219X-1-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155408/
https://www.ncbi.nlm.nih.gov/pubmed/21845232
http://dx.doi.org/10.1186/2191-219X-1-1

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