Further Activation of FLT3 Mutants by FLT3 Ligand

Somatic mutations of FLT3 involving internal tandem duplication (ITD) of the juxtamembrane domainor point mutations in the kinase domain (TKD) appear to activate FLT3 in a FLT3 ligand (FL) - independent manner. To determine whether or not FLT3 mutants respond to FL for their activation, a FL-deficie...

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Detalles Bibliográficos
Autores principales: Zheng, Rui, Bailey, Emily, Nguyen, Bao, Yang, Xiaochuan, Piloto, Obdulio, Levis, Mark, Small, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155740/
https://www.ncbi.nlm.nih.gov/pubmed/21516120
http://dx.doi.org/10.1038/onc.2011.110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155740/
https://www.ncbi.nlm.nih.gov/pubmed/21516120
http://dx.doi.org/10.1038/onc.2011.110

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