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Properties and Crystal Structure of Methylenetetrahydrofolate Reductase from Thermus thermophilus HB8

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in homocysteine metabolism. Despite considerable genetic and clinical attention, the reaction mechanism and regulation of this enzyme are not fully understood because of difficult production and poor stability. Wh...

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Detalles Bibliográficos
Autores principales: Igari, Sayaka, Ohtaki, Akashi, Yamanaka, Yasuaki, Sato, Yuichi, Yohda, Masafumi, Odaka, Masafumi, Noguchi, Keiichi, Yamada, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156243/
https://www.ncbi.nlm.nih.gov/pubmed/21858212
http://dx.doi.org/10.1371/journal.pone.0023716