Targeting RNA by Small Molecules: Comparative Structural and Thermodynamic Aspects of Aristololactam-β-D-glucoside and Daunomycin Binding to tRNA(phe)

BACKGROUND: Interaction of aristololactam-β-D-glucoside and daunomycin with tRNA(phe) was investigated using various biophysical techniques. METHODOLOGY/PRINCIPAL FINDINGS: Absorption and fluorescence studies revealed that both the compounds bind tRNA(phe) non-cooperatively. The binding of daunomyci...

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Detalles Bibliográficos
Autores principales: Das, Abhi, Bhadra, Kakali, Suresh Kumar, Gopinatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156712/
https://www.ncbi.nlm.nih.gov/pubmed/21858023
http://dx.doi.org/10.1371/journal.pone.0023186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156712/
https://www.ncbi.nlm.nih.gov/pubmed/21858023
http://dx.doi.org/10.1371/journal.pone.0023186

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