Molecular Dynamics Analysis Reveals Structural Insights into Mechanism of Nicotine N-Demethylation Catalyzed by Tobacco Cytochrome P450 Mono-Oxygenase

CYP82E4, a cytochrome P450 monooxygenase, has nicotine N-demethylase (NND) activity, which mediates the bioconversion of nicotine into nornicotine in senescing tobacco leaves. Nornicotine is a precursor of the carcinogen, tobacco-specific nitrosamine. CYP82E3 is an ortholog of CYP82E4 with 95% seque...

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Detalles Bibliográficos
Autores principales: Wang, Shan, Yang, Shuo, An, Baiyi, Wang, Shichen, Yin, Yuejia, Lu, Yang, Xu, Ying, Hao, Dongyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156719/
https://www.ncbi.nlm.nih.gov/pubmed/21858078
http://dx.doi.org/10.1371/journal.pone.0023342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156719/
https://www.ncbi.nlm.nih.gov/pubmed/21858078
http://dx.doi.org/10.1371/journal.pone.0023342

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