Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects spinal cord and cortical motor neurons. An increasing amount of evidence suggests that mitochondrial dysfunction contributes to motor neuron death in ALS. Peroxisome proliferator-activated recepto...

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Detalles Bibliográficos
Autores principales: Zhao, Wei, Varghese, Merina, Yemul, Shrishailam, Pan, Yong, Cheng, Alice, Marano, Paul, Hassan, Sadiq, Vempati, Prashant, Chen, Fei, Qian, Xianjuan, Pasinetti, Giulio M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156746/
https://www.ncbi.nlm.nih.gov/pubmed/21771318
http://dx.doi.org/10.1186/1750-1326-6-51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156746/
https://www.ncbi.nlm.nih.gov/pubmed/21771318
http://dx.doi.org/10.1186/1750-1326-6-51

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