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Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects spinal cord and cortical motor neurons. An increasing amount of evidence suggests that mitochondrial dysfunction contributes to motor neuron death in ALS. Peroxisome proliferator-activated recepto...

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Detalles Bibliográficos
Autores principales:	Zhao, Wei, Varghese, Merina, Yemul, Shrishailam, Pan, Yong, Cheng, Alice, Marano, Paul, Hassan, Sadiq, Vempati, Prashant, Chen, Fei, Qian, Xianjuan, Pasinetti, Giulio M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156746/ https://www.ncbi.nlm.nih.gov/pubmed/21771318 http://dx.doi.org/10.1186/1750-1326-6-51

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