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Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head

BACKGROUND: The pathogenesis of osteonecrosis of the femoral head (ONFH) has been implicated in hypofibrinolysis and blood supply interruption. Previous studies have demonstrated that decreased fibrinolytic activity due to elevated plasminogen activator inhibitor-1 (PAI-1) levels correlates with ONF...

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Detalles Bibliográficos
Autores principales: Kim, Hye- Ok, Cho, Chang- Hoon, Cho, Yoon- Je, Cho, Seong- Ho, Yoon, Kyung- Sik, Kim, Kang- Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156806/
https://www.ncbi.nlm.nih.gov/pubmed/21752301
http://dx.doi.org/10.1186/1471-2474-12-160