Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise

BACKGROUND: Inbred individuals reared in controlled environments display considerable variance in many complex traits but the underlying cause of this intangible variation has been an enigma. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process. RESULTS: I...

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Detalles Bibliográficos
Autores principales: Whitelaw, Nadia C, Chong, Suyinn, Morgan, Daniel K, Nestor, Colm, Bruxner, Timothy J, Ashe, Alyson, Lambley, Eleanore, Meehan, Richard, Whitelaw, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156950/
https://www.ncbi.nlm.nih.gov/pubmed/21092094
http://dx.doi.org/10.1186/gb-2010-11-11-r111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156950/
https://www.ncbi.nlm.nih.gov/pubmed/21092094
http://dx.doi.org/10.1186/gb-2010-11-11-r111

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