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Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise
BACKGROUND: Inbred individuals reared in controlled environments display considerable variance in many complex traits but the underlying cause of this intangible variation has been an enigma. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process. RESULTS: I...
Autores principales: | Whitelaw, Nadia C, Chong, Suyinn, Morgan, Daniel K, Nestor, Colm, Bruxner, Timothy J, Ashe, Alyson, Lambley, Eleanore, Meehan, Richard, Whitelaw, Emma |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156950/ https://www.ncbi.nlm.nih.gov/pubmed/21092094 http://dx.doi.org/10.1186/gb-2010-11-11-r111 |
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