Cargando…

Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing

BACKGROUND: To identify potential tumor suppressor genes, genome-wide data from exome and transcriptome sequencing were combined to search for genes with loss of heterozygosity and allele-specific expression. The analysis was conducted on the breast cancer cell line HCC1954, and a lymphoblast cell l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Qi, Kirkness, Ewen F, Caballero, Otavia L, Galante, Pedro A, Parmigiani, Raphael B, Edsall, Lee, Kuan, Samantha, Ye, Zhen, Levy, Samuel, Vasconcelos, Ana Tereza R, Ren, Bing, de Souza, Sandro J, Camargo, Anamaria A, Simpson, Andrew JG, Strausberg, Robert L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156953/ https://www.ncbi.nlm.nih.gov/pubmed/21108794 http://dx.doi.org/10.1186/gb-2010-11-11-r114

Ejemplares similares

Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual
por: Galante, Pedro A. F., et al.
Publicado: (2011)

Differential Evolution of MAGE Genes Based on Expression Pattern and Selection Pressure
por: Zhao, Qi, et al.
Publicado: (2012)

Vaccines and early breast cancer
por: Caballero, Otavia L, et al.
Publicado: (2014)

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy
por: Donnard, Elisa, et al.
Publicado: (2014)

Monoclonal antibodies for the therapy of cancer
por: Simpson, Andrew, et al.
Publicado: (2014)

Genetic Variation in an Individual Human Exome
por: Ng, Pauline C., et al.
Publicado: (2008)

Gene Copy-Number Polymorphism Caused by Retrotransposition in Humans
por: Schrider, Daniel R., et al.
Publicado: (2013)

Alternative Spliced Transcripts as Cancer Markers
por: Caballero, Otavia L., et al.
Publicado: (2001)

The HuRef Browser: a web resource for individual human genomics
por: Axelrod, Nelson, et al.
Publicado: (2009)

Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast
por: Caballero, Otavia L., et al.
Publicado: (2013)

Alternative Polyadenylation Allows Differential Negative Feedback of Human miRNA miR-579 on Its Host Gene ZFR
por: Hinske, Ludwig Christian, et al.
Publicado: (2015)

Molecular diagnosis of putative Stargardt disease probands by exome sequencing
por: Strom, Samuel P, et al.
Publicado: (2012)

Whole exome sequencing reveals putatively novel associations in retinopathies and drusen formation
por: Doucette, Lance P., et al.
Publicado: (2021)

Survey Sequencing and Comparative Analysis of the Elephant Shark (Callorhinchus milii) Genome
por: Venkatesh, Byrappa, et al.
Publicado: (2007)

RASSF6; the Putative Tumor Suppressor of the RASSF Family
por: Iwasa, Hiroaki, et al.
Publicado: (2015)

Exome sequence analysis of Kaposiform hemangioendothelioma: identification of putative driver mutations
por: Egashira, Sho, et al.
Publicado: (2016)

Whole-genome cancer analysis as an approach to deeper understanding of tumour biology
por: Strausberg, R L, et al.
Publicado: (2010)

Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN.
por: Gray, I. C., et al.
Publicado: (1998)

Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer
por: De Faveri, L E, et al.
Publicado: (2013)

CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens
por: Almeida, Luiz Gonzaga, et al.
Publicado: (2009)

Structure of putative tumor suppressor ALDH1L1
por: Tsybovsky, Yaroslav, et al.
Publicado: (2022)

The use of personalized biomarkers and liquid biopsies to monitor treatment response and disease recurrence in locally advanced rectal cancer after neoadjuvant chemoradiation
por: Carpinetti, Paola, et al.
Publicado: (2015)

Novel putative drivers revealed by targeted exome sequencing of advanced solid tumors
por: Pannuti, Antonio, et al.
Publicado: (2018)

Whole‐exome sequencing of ovarian cancer families uncovers putative predisposition genes
por: Zhu, Qianqian, et al.
Publicado: (2019)

Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
por: Camargo, Rosalinda Yasato, et al.
Publicado: (2018)

Targeting MAGE-C1/CT7 Expression Increases Cell Sensitivity to the Proteasome Inhibitor Bortezomib in Multiple Myeloma Cell Lines
por: de Carvalho, Fabricio, et al.
Publicado: (2011)

Exome Sequencing in 53 Sporadic Cases of Schizophrenia Identifies 18 Putative Candidate Genes
por: Guipponi, Michel, et al.
Publicado: (2014)

Chromosomal localization of putative tumor-suppressor genes in several human cancers.
por: Yokota, J, et al.
Publicado: (1991)

The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy
por: Seed, Robert I., et al.
Publicado: (2019)

Quality control of the sheep bacterial artificial chromosome library, CHORI-243
por: Ratnakumar, Abhirami, et al.
Publicado: (2010)

Centrosomal Localisation of the Cancer/Testis (CT) Antigens NY-ESO-1 and MAGE-C1 Is Regulated by Proteasome Activity in Tumour Cells
por: Pagotto, Anna, et al.
Publicado: (2013)

Correction: Exome Sequencing in 53 Sporadic Cases of Schizophrenia Identifies 18 Putative Candidate Genes
por: Guipponi, Michel, et al.
Publicado: (2015)

Centenarian Exomes as a Tool for Evaluating the Clinical Relevance of Germline Tumor Suppressor Mutations
por: Balabanski, Lubomir, et al.
Publicado: (2020)

Computational Survey of FHIT, A Putative Human Tumor Suppressor, Truncates Structure
por: Eslamparast, Ameneh, et al.
Publicado: (2014)

Subchromosomal Mapping of a Putative Transformation Suppressor Gene on Human Chromosome 1
por: Horikawa, Izumi, et al.
Publicado: (1995)

EPLIN, a Putative Tumour Suppressor in Colorectal Cancer, Implications in Drug Resistance
por: Zeng, Jianyuan, et al.
Publicado: (2022)

Sense-antisense pairs in mammals: functional and evolutionary considerations
por: Galante, Pedro AF, et al.
Publicado: (2007)

Tumor microenvironments, the immune system and cancer survival
por: Strausberg, Robert L
Publicado: (2005)

Talkin’ Omics
por: Strausberg, Robert L.
Publicado: (2001)

Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation
por: Greco, Sonia A, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_bhdn9e6irpub1hrr30iamq78r4