Quake: quality-aware detection and correction of sequencing errors

We introduce Quake, a program to detect and correct errors in DNA sequencing reads. Using a maximum likelihood approach incorporating quality values and nucleotide specific miscall rates, Quake achieves the highest accuracy on realistically simulated reads. We further demonstrate substantial improve...

Descripción completa

Detalles Bibliográficos
Autores principales: Kelley, David R, Schatz, Michael C, Salzberg, Steven L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156955/
https://www.ncbi.nlm.nih.gov/pubmed/21114842
http://dx.doi.org/10.1186/gb-2010-11-11-r116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156955/
https://www.ncbi.nlm.nih.gov/pubmed/21114842
http://dx.doi.org/10.1186/gb-2010-11-11-r116

Ejemplares similares