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Quake: quality-aware detection and correction of sequencing errors
We introduce Quake, a program to detect and correct errors in DNA sequencing reads. Using a maximum likelihood approach incorporating quality values and nucleotide specific miscall rates, Quake achieves the highest accuracy on realistically simulated reads. We further demonstrate substantial improve...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156955/ https://www.ncbi.nlm.nih.gov/pubmed/21114842 http://dx.doi.org/10.1186/gb-2010-11-11-r116 |