Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials

BACKGROUND: The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke. A previous overview showed that the effects were greatest in regions with low dietary folate consumption, but differentiation between the effect of folate and small-stud...

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Detalles Bibliográficos
Autores principales: Holmes, Michael V, Newcombe, Paul, Hubacek, Jaroslav A, Sofat, Reecha, Ricketts, Sally L, Cooper, Jackie, Breteler, Monique MB, Bautista, Leonelo E, Sharma, Pankaj, Whittaker, John C, Smeeth, Liam, Fowkes, F Gerald R, Algra, Ale, Shmeleva, Veronika, Szolnoki, Zoltan, Roest, Mark, Linnebank, Michael, Zacho, Jeppe, Nalls, Michael A, Singleton, Andrew B, Ferrucci, Luigi, Hardy, John, Worrall, Bradford B, Rich, Stephen S, Matarin, Mar, Norman, Paul E, Flicker, Leon, Almeida, Osvaldo P, van Bockxmeer, Frank M, Shimokata, Hiroshi, Khaw, Kay-Tee, Wareham, Nicholas J, Bobak, Martin, Sterne, Jonathan AC, Smith, George Davey, Talmud, Philippa J, van Duijn, Cornelia, Humphries, Steve E, Price, Jackie F, Ebrahim, Shah, Lawlor, Debbie A, Hankey, Graeme J, Meschia, James F, Sandhu, Manjinder S, Hingorani, Aroon D, Casas, Juan P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lancet Publishing Group 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156981/
https://www.ncbi.nlm.nih.gov/pubmed/21803414
http://dx.doi.org/10.1016/S0140-6736(11)60872-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156981/
https://www.ncbi.nlm.nih.gov/pubmed/21803414
http://dx.doi.org/10.1016/S0140-6736(11)60872-6

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