Androgen-induced TOP2B mediated double strand breaks and prostate cancer gene rearrangements

DNA double strand breaks (DSB) can lead to development of genomic rearrangements, which are hallmarks of cancer. TMPRSS2-ERG gene fusions in prostate cancer (PCa) are among the most common genomic rearrangements observed in human cancer. We show that androgen signaling promotes co-recruitment of and...

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Detalles Bibliográficos
Autores principales: Haffner, Michael C., Aryee, Martin J., Toubaji, Antoun, Esopi, David M., Albadine, Roula, Gurel, Bora, Isaacs, William B., Bova, G. Steven, Liu, Wennuan, Xu, Jianfeng, Meeker, Alan K., Netto, George, De Marzo, Angelo M., Nelson, William G., Yegnasubramanian, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157086/
https://www.ncbi.nlm.nih.gov/pubmed/20601956
http://dx.doi.org/10.1038/ng.613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157086/
https://www.ncbi.nlm.nih.gov/pubmed/20601956
http://dx.doi.org/10.1038/ng.613

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