Cargando…

Androgen-induced TOP2B mediated double strand breaks and prostate cancer gene rearrangements

DNA double strand breaks (DSB) can lead to development of genomic rearrangements, which are hallmarks of cancer. TMPRSS2-ERG gene fusions in prostate cancer (PCa) are among the most common genomic rearrangements observed in human cancer. We show that androgen signaling promotes co-recruitment of and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haffner, Michael C., Aryee, Martin J., Toubaji, Antoun, Esopi, David M., Albadine, Roula, Gurel, Bora, Isaacs, William B., Bova, G. Steven, Liu, Wennuan, Xu, Jianfeng, Meeker, Alan K., Netto, George, De Marzo, Angelo M., Nelson, William G., Yegnasubramanian, Srinivasan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157086/ https://www.ncbi.nlm.nih.gov/pubmed/20601956 http://dx.doi.org/10.1038/ng.613

Ejemplares similares

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
por: Haffner, Michael C., et al.
Publicado: (2011)

Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer
por: Brennen, W. Nathaniel, et al.
Publicado: (2021)

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations
por: Gerber, Jonathan M., et al.
Publicado: (2013)

Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences
por: Yegnasubramanian, Srinivasan, et al.
Publicado: (2011)

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination
por: Haffner, Michael C., et al.
Publicado: (2017)

Role of androgen receptor splice variant 7 (AR-V7) in prostate cancer resistance to 2(nd) generation androgen receptor signaling inhibitors
por: Zhu, Yezi, et al.
Publicado: (2020)

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers
por: Esopi, David, et al.
Publicado: (2020)

Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing
por: Pham, Minh-Tam, et al.
Publicado: (2022)

Copy Number Analysis Indicates Monoclonal Origin of Lethal Metastatic Prostate Cancer
por: Liu, Wennuan, et al.
Publicado: (2009)

Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylation
por: Yegnasubramanian, Srinivasan, et al.
Publicado: (2006)

Renal cell carcinoma associated with peritumoral sarcoid-like reaction without intratumoral granuloma
por: Ouellet, Simon, et al.
Publicado: (2012)

CD38 is methylated in prostate cancer and regulates extracellular NAD(+)
por: Mottahedeh, Jack, et al.
Publicado: (2018)

The expression of AURKA is androgen regulated in castration-resistant prostate cancer
por: Kivinummi, Kati, et al.
Publicado: (2017)

Ectopic ACTH Cushing's syndrome caused by a large-cell neuroendocrine lung carcinoma responding to desmopressin
por: Larose, Stéphanie, et al.
Publicado: (2023)

SAT321 Ectopic ACTH Cushing's Syndrome Caused By A Large-cell Neuroendocrine Lung Carcinoma Responding To Desmopressin
por: Larose, Stephanie, et al.
Publicado: (2023)

The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
por: Garay, Joseph P, et al.
Publicado: (2012)

Does Valproic Acid Induce Neuroendocrine Differentiation in Prostate Cancer?
por: Sidana, Abhinav, et al.
Publicado: (2011)

Translation of genomics and epigenomics in prostate cancer: progress and promising directions
por: Liu, Wennuan, et al.
Publicado: (2016)

Generation of Gross Chromosomal Rearrangements by a Single Engineered DNA Double Strand Break
por: Qiu, Zhijun, et al.
Publicado: (2017)

Androgen receptor gene mutation, rearrangement, polymorphism
por: Eisermann, Kurtis, et al.
Publicado: (2013)

Health inequity drives disease biology to create disparities in prostate cancer outcomes
por: Nelson, William G., et al.
Publicado: (2022)

Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC
por: Sena, Laura A., et al.
Publicado: (2022)

Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair
por: McGinty, Ryan J., et al.
Publicado: (2017)

Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism
por: Al-Zain, Amr M., et al.
Publicado: (2023)

Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer
por: Sharad, Shashwat, et al.
Publicado: (2014)

Prostate Adenocarcinomas Aberrantly Expressing p63 Are Molecularly Distinct from Usual-Type Prostatic Adenocarcinomas
por: Tan, Hsueh-Li, et al.
Publicado: (2014)

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks
por: Barfeld, Stefan J., et al.
Publicado: (2017)

Identification of New Differentially Methylated Genes That Have Potential Functional Consequences in Prostate Cancer
por: Kim, Jin W., et al.
Publicado: (2012)

Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer
por: Wu, Ray-Chang, et al.
Publicado: (2019)

Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma
por: Orr, Brent A., et al.
Publicado: (2012)

A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs
por: Giovinazzo, Hugh, et al.
Publicado: (2019)

The Globular State of the Single-Stranded RNA: Effect of the Secondary Structure Rearrangements
por: Grigoryan, Zareh A., et al.
Publicado: (2015)

If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease
por: Sfanos, Karen S., et al.
Publicado: (2019)

Assessing the order of critical alterations in prostate cancer development and progression by IHC: further evidence that PTEN loss occurs subsequent to ERG gene fusion
por: Gumuskaya, Berrak, et al.
Publicado: (2013)

DNA Double-Strand Breaks Affect Chromosomal Rearrangements during Methotrexate-Mediated Gene Amplification in Chinese Hamster Ovary Cells
por: Baik, Jong Youn, et al.
Publicado: (2021)

Identification of Replication Competent Murine Gammaretroviruses in Commonly Used Prostate Cancer Cell Lines
por: Sfanos, Karen Sandell, et al.
Publicado: (2011)

Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies
por: Munari, Enrico, et al.
Publicado: (2016)

DNA alterations in the tumor genome and their associations with clinical outcome in prostate cancer
por: Liu, Wennuan
Publicado: (2016)

A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts
por: Ribas, Judit, et al.
Publicado: (2012)

Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
por: Henzler, Christine, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gvbe47h00cub2m32au2vbrni36