Role of Heterozygous APC Mutation in Niche Succession and Initiation of Colorectal Cancer – A Computational Study

Mutations in the adenomatous polyposis coli (APC) gene are found in most colorectal cancers. They cause constitutive activation of proliferative pathways when both alleles of the gene are mutated. However studies on individuals with familial adenomatous polyposis (FAP) have shown that a single mutat...

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Detalles Bibliográficos
Autores principales: Sasikumar, Roschen, Rejitha, John Raji, Binumon, Ponthananiyil Kumaran, Manoj, Muraleedharan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157318/
https://www.ncbi.nlm.nih.gov/pubmed/21857949
http://dx.doi.org/10.1371/journal.pone.0022720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157318/
https://www.ncbi.nlm.nih.gov/pubmed/21857949
http://dx.doi.org/10.1371/journal.pone.0022720

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