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Permeation through the Cell Membrane of a Boron-Based β-Lactamase Inhibitor

Bacteria express beta-lactamases to counteract the beneficial action of antibiotics. Benzo[b]-thiophene-2-boronic acid (BZB) derivatives are β-lactamase inhibitors and, as such, promising compounds to be associated with β-lactam antibacterial therapies. The uncharged form of BZB, in particular, is s...

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Detalles Bibliográficos
Autores principales: Minozzi, Manuela, Lattanzi, Gianluca, Benz, Roland, Costi, Maria P., Venturelli, Alberto, Carloni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157353/
https://www.ncbi.nlm.nih.gov/pubmed/21858024
http://dx.doi.org/10.1371/journal.pone.0023187