Effects of Clinically Relevant MPL Mutations in the Transmembrane Domain Revealed at the Atomic Level through Computational Modeling

BACKGROUND: Mutations in the thrombopoietin receptor (MPL) may activate relevant pathways and lead to chronic myeloproliferative neoplasms (MPNs). The mechanisms of MPL activation remain elusive because of a lack of experimental structures. Modern computational biology techniques were utilized to ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Tai-Sung, Kantarjian, Hagop, Ma, Wanlong, Yeh, Chen-Hsiung, Giles, Francis, Albitar, Maher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157383/
https://www.ncbi.nlm.nih.gov/pubmed/21858098
http://dx.doi.org/10.1371/journal.pone.0023396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157383/
https://www.ncbi.nlm.nih.gov/pubmed/21858098
http://dx.doi.org/10.1371/journal.pone.0023396

Ejemplares similares