Systematic Spatial Bias in DNA Microarray Hybridization Is Caused by Probe Spot Position-Dependent Variability in Lateral Diffusion

BACKGROUND: The hybridization of nucleic acid targets with surface-immobilized probes is a widely used assay for the parallel detection of multiple targets in medical and biological research. Despite its widespread application, DNA microarray technology still suffers from several biases and lack of...

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Detalles Bibliográficos
Autores principales: Steger, Doris, Berry, David, Haider, Susanne, Horn, Matthias, Wagner, Michael, Stocker, Roman, Loy, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157431/
https://www.ncbi.nlm.nih.gov/pubmed/21858215
http://dx.doi.org/10.1371/journal.pone.0023727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157431/
https://www.ncbi.nlm.nih.gov/pubmed/21858215
http://dx.doi.org/10.1371/journal.pone.0023727

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