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One-Step Preservation of Phosphoproteins and Tissue Morphology at Room Temperature for Diagnostic and Research Specimens

BACKGROUND: There is an urgent need to measure phosphorylated cell signaling proteins in cancer tissue for the individualization of molecular targeted kinase inhibitor therapy. However, phosphoproteins fluctuate rapidly following tissue procurement. Snap-freezing preserves phosphoproteins, but is un...

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Detalles Bibliográficos
Autores principales: Mueller, Claudius, Edmiston, Kirsten H., Carpenter, Calvin, Gaffney, Eoin, Ryan, Ciara, Ward, Ronan, White, Susan, Memeo, Lorenzo, Colarossi, Cristina, Petricoin, Emanuel F., Liotta, Lance A., Espina, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157466/
https://www.ncbi.nlm.nih.gov/pubmed/21858221
http://dx.doi.org/10.1371/journal.pone.0023780