An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD(+)-Dependent Glutamate Dehydrogenase

Sequence and structure comparisons of various glutamate dehydrogenases (GDH) and other nicotinamide nucleotide-dependent dehydrogenases have potentially implicated certain residues in coenzyme binding and discrimination. We have mutated key residues in Clostridium symbiosum NAD(+)-specific GDH to in...

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Detalles Bibliográficos
Autores principales: Griffin, Joanna, Engel, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157743/
https://www.ncbi.nlm.nih.gov/pubmed/21876794
http://dx.doi.org/10.4061/2011/595793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157743/
https://www.ncbi.nlm.nih.gov/pubmed/21876794
http://dx.doi.org/10.4061/2011/595793

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