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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

The number of significant genetic associations with common complex traits is constantly increasing. However, most of these associations have not been understood at molecular level. One of the mechanisms mediating the effect of DNA variants on phenotypes is gene expression, which has been shown to be...

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Detalles Bibliográficos
Autores principales: Paracchini, Silvia, Monaco, Anthony P., Knight, Julian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157858/
https://www.ncbi.nlm.nih.gov/pubmed/21085102
http://dx.doi.org/10.3791/2279