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Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins

Highly pathogenic avian influenza A (HPAI) viruses of the H5N1 subtype have recently emerged from avian zoonotic reservoirs to cause fatal human disease. Adaptation of HPAI virus RNA-dependent RNA polymerase (PB1, PB2, and PA proteins) and nucleoprotein (NP) to interactions with mammalian host prote...

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Detalles Bibliográficos
Autores principales: Bortz, Eric, Westera, Liset, Maamary, Jad, Steel, John, Albrecht, Randy A., Manicassamy, Balaji, Chase, Geoffrey, Martínez-Sobrido, Luis, Schwemmle, Martin, García-Sastre, Adolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157893/
https://www.ncbi.nlm.nih.gov/pubmed/21846828
http://dx.doi.org/10.1128/mBio.00151-11