Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

In the current work, unanticipated synthetic byproducts were obtained arising from alkylation of the δ(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. For the highest affinity byproduct, bearing a C(6)H(5)(CH(2))(8)– gro...

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Detalles Bibliográficos
Autores principales: Liu, Fa, Park, Jung-Eun, Qian, Wen-Jian, Lim, Dan, Gräber, Martin, Berg, Thorsten, Yaffe, Michael B., Lee, Kyung S., Burke, Terrence R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158281/
https://www.ncbi.nlm.nih.gov/pubmed/21765407
http://dx.doi.org/10.1038/nchembio.614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158281/
https://www.ncbi.nlm.nih.gov/pubmed/21765407
http://dx.doi.org/10.1038/nchembio.614

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