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Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel
In the current work, unanticipated synthetic byproducts were obtained arising from alkylation of the δ(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. For the highest affinity byproduct, bearing a C(6)H(5)(CH(2))(8)– gro...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158281/ https://www.ncbi.nlm.nih.gov/pubmed/21765407 http://dx.doi.org/10.1038/nchembio.614 |