Amyloid-β Forms Fibrils by Nucleated Conformational Conversion of Oligomers

Aβ amyloidogenesis is reported to occur via a nucleated polymerization mechanism, if so the energetically unfavorable oligomeric nucleus should be very hard to detect. However, many laboratories have detected early non-fibrillar Aβ oligomers without observing amyloid fibrils, suggesting a mechanisti...

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Detalles Bibliográficos
Autores principales: Lee, Jiyong, Culyba, Elizabeth K., Powers, Evan T., Kelly, Jeffery W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158298/
https://www.ncbi.nlm.nih.gov/pubmed/21804535
http://dx.doi.org/10.1038/nchembio.624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158298/
https://www.ncbi.nlm.nih.gov/pubmed/21804535
http://dx.doi.org/10.1038/nchembio.624

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