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Amyloid-β Forms Fibrils by Nucleated Conformational Conversion of Oligomers
Aβ amyloidogenesis is reported to occur via a nucleated polymerization mechanism, if so the energetically unfavorable oligomeric nucleus should be very hard to detect. However, many laboratories have detected early non-fibrillar Aβ oligomers without observing amyloid fibrils, suggesting a mechanisti...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158298/ https://www.ncbi.nlm.nih.gov/pubmed/21804535 http://dx.doi.org/10.1038/nchembio.624 |