Bid can mediate a pro-apoptotic response to etoposide and ionizing radiation without cleavage in its unstructured loop and in the absence of p53

BH3-only protein Bid is a key player in death receptor-induced apoptosis, because it provides the link with the mitochondrial route for caspase activation. In this pathway, Bid is activated upon cleavage by caspase-8. Its BH3 domain-containing carboxy-terminal fragment subsequently provokes mitochon...

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Detalles Bibliográficos
Autores principales: Maas, C, de Vries, E, Tait, S W G, Borst, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158540/
https://www.ncbi.nlm.nih.gov/pubmed/21423217
http://dx.doi.org/10.1038/onc.2011.75

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158540/
https://www.ncbi.nlm.nih.gov/pubmed/21423217
http://dx.doi.org/10.1038/onc.2011.75

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