Tuberous sclerosis complex 1 (Tsc1) enforces quiescence of naive T cells to promote immune homeostasis and function

The mechanisms that regulate T cell quiescence are poorly understood. We report that tuberous sclerosis complex 1 (Tsc1) establishes a quiescence program in naive T cells by controlling cell size, cell cycle entry, and responses to T cell receptor stimulation. Loss of quiescence predisposed Tsc1-def...

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Detalles Bibliográficos
Autores principales: Yang, Kai, Neale, Geoffrey, Green, Douglas R., He, Weifeng, Chi, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158818/
https://www.ncbi.nlm.nih.gov/pubmed/21765414
http://dx.doi.org/10.1038/ni.2068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158818/
https://www.ncbi.nlm.nih.gov/pubmed/21765414
http://dx.doi.org/10.1038/ni.2068

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