DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

DNA double-strand breaks (DSBs) can induce chromosomal aberrations and carcinogenesis and their correct repair is crucial for genetic stability. The cellular response to DSBs depends on damage signaling including the phosphorylation of the histone H2AX (γH2AX). However, a lack of γH2AX formation in...

Descripción completa

Detalles Bibliográficos
Autores principales: Jakob, Burkhard, Splinter, Jörn, Conrad, Sandro, Voss, Kay-Obbe, Zink, Daniele, Durante, Marco, Löbrich, Markus, Taucher-Scholz, Gisela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159438/
https://www.ncbi.nlm.nih.gov/pubmed/21511815
http://dx.doi.org/10.1093/nar/gkr230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159438/
https://www.ncbi.nlm.nih.gov/pubmed/21511815
http://dx.doi.org/10.1093/nar/gkr230

Ejemplares similares