Native homing endonucleases can target conserved genes in humans and in animal models

In recent years, both homing endonucleases (HEases) and zinc-finger nucleases (ZFNs) have been engineered and selected for the targeting of desired human loci for gene therapy. However, enzyme engineering is lengthy and expensive and the off-target effect of the manufactured endonucleases is difficu...

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Detalles Bibliográficos
Autores principales: Barzel, Adi, Privman, Eyal, Peeri, Michael, Naor, Adit, Shachar, Einat, Burstein, David, Lazary, Rona, Gophna, Uri, Pupko, Tal, Kupiec, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159444/
https://www.ncbi.nlm.nih.gov/pubmed/21525128
http://dx.doi.org/10.1093/nar/gkr242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159444/
https://www.ncbi.nlm.nih.gov/pubmed/21525128
http://dx.doi.org/10.1093/nar/gkr242

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