Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis

Deficiency in Artemis is associated with lack of V(D)J recombination, sensitivity to radiation and radiomimetic drugs, and failure to repair a subset of DNA double-strand breaks (DSBs). Artemis harbors an endonuclease activity that trims both 5′- and 3′-ends of DSBs. To examine whether endonucleolyt...

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Detalles Bibliográficos
Autores principales: Mohapatra, Susovan, Kawahara, Misako, Khan, Imran S., Yannone, Steven M., Povirk, Lawrence F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159448/
https://www.ncbi.nlm.nih.gov/pubmed/21531702
http://dx.doi.org/10.1093/nar/gkr257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159448/
https://www.ncbi.nlm.nih.gov/pubmed/21531702
http://dx.doi.org/10.1093/nar/gkr257

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