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The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks
Type II DNA topoisomerases (topos) catalyse changes in DNA topology by passing one double-stranded DNA segment through another. This reaction is essential to processes such as replication and transcription, but carries with it the inherent danger of permanent double-strand break (DSB) formation. All...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159449/ https://www.ncbi.nlm.nih.gov/pubmed/21525132 http://dx.doi.org/10.1093/nar/gkr258 |