Stimulation of Wild-Type, F508del- and G551D-CFTR Chloride Channels by Non-Toxic Modified pyrrolo[2,3-b]pyrazine Derivatives

Cystic fibrosis (CF) is a major inherited disorder involving abnormalities of fluid and electrolyte transport in a number of different organs due to abnormal function of cystic fibrosis transmembrane conductance regulator (CFTR) protein. We recently identified a family of CFTR activators, which cont...

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Detalles Bibliográficos
Autores principales: Dannhoffer, Luc, Billet, Arnaud, Jollivet, Mathilde, Melin-Heschel, Patricia, Faveau, Christelle, Becq, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159890/
https://www.ncbi.nlm.nih.gov/pubmed/21897819
http://dx.doi.org/10.3389/fphar.2011.00048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159890/
https://www.ncbi.nlm.nih.gov/pubmed/21897819
http://dx.doi.org/10.3389/fphar.2011.00048

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