Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity

The AKT protooncogene mediates many cellular processes involved in normal development and disease states such as cancer. The three structurally similar isoforms: AKT1, AKT2, and AKT3 exhibit both functional redundancy and isoform-specific functions; however the basis for their differential signallin...

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Detalles Bibliográficos
Autores principales: Lee, Rachel S., House, Colin M., Cristiano, Briony E., Hannan, Ross D., Pearson, Richard B., Hannan, Katherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160084/
https://www.ncbi.nlm.nih.gov/pubmed/21869924
http://dx.doi.org/10.4061/2011/720985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160084/
https://www.ncbi.nlm.nih.gov/pubmed/21869924
http://dx.doi.org/10.4061/2011/720985

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