Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome (DS). Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and accordingly treatment with GABA...

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Detalles Bibliográficos
Autores principales: Braudeau, J, Delatour, B, Duchon, A, Pereira, P Lopes, Dauphinot, L, de Chaumont, F, Olivo-Marin, J-C, Dodd, RH, Hérault, Y, Potier, M-C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2011
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160204/
https://www.ncbi.nlm.nih.gov/pubmed/21693554
http://dx.doi.org/10.1177/0269881111405366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160204/
https://www.ncbi.nlm.nih.gov/pubmed/21693554
http://dx.doi.org/10.1177/0269881111405366

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