Genetic Variants of Human Granzyme B Predict Transplant Outcomes after HLA Matched Unrelated Bone Marrow Transplantation for Myeloid Malignancies

Serine protease granzyme B plays important roles in infections, autoimmunity, transplant rejection, and antitumor immunity. A triple-mutated granzyme B variant that encodes three amino substitutions (Q48R, P88A, and Y245H) has been reported to have altered biological functions. In the polymorphism r...

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Detalles Bibliográficos
Autores principales: Espinoza, Luis J., Takami, Akiyoshi, Nakata, Katsuya, Yamada, Kayoko, Onizuka, Makoto, Kawase, Takakazu, Sao, Hiroshi, Akiyama, Hideki, Miyamura, Koichi, Okamoto, Shinichiro, Inoue, Masami, Fukuda, Takahiro, Morishima, Yasuo, Kodera, Yoshihisa, Nakao, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160316/
https://www.ncbi.nlm.nih.gov/pubmed/21886827
http://dx.doi.org/10.1371/journal.pone.0023827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160316/
https://www.ncbi.nlm.nih.gov/pubmed/21886827
http://dx.doi.org/10.1371/journal.pone.0023827

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