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Genetic Variants of Human Granzyme B Predict Transplant Outcomes after HLA Matched Unrelated Bone Marrow Transplantation for Myeloid Malignancies
Serine protease granzyme B plays important roles in infections, autoimmunity, transplant rejection, and antitumor immunity. A triple-mutated granzyme B variant that encodes three amino substitutions (Q48R, P88A, and Y245H) has been reported to have altered biological functions. In the polymorphism r...
Autores principales: | Espinoza, Luis J., Takami, Akiyoshi, Nakata, Katsuya, Yamada, Kayoko, Onizuka, Makoto, Kawase, Takakazu, Sao, Hiroshi, Akiyama, Hideki, Miyamura, Koichi, Okamoto, Shinichiro, Inoue, Masami, Fukuda, Takahiro, Morishima, Yasuo, Kodera, Yoshihisa, Nakao, Shinji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160316/ https://www.ncbi.nlm.nih.gov/pubmed/21886827 http://dx.doi.org/10.1371/journal.pone.0023827 |
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