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An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV(1): a longitudinal retrospective cohort study

BACKGROUND: An Nrf2-dependent response is a central protective mechanism against oxidative stress. We propose that particular genetic variants of the Nrf2 gene may be associated with a rapid forced expiratory volume in one second (FEV(1)) decline induced by cigarette smoking. METHODS: We conducted a...

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Detalles Bibliográficos
Autores principales: Masuko, Hironori, Sakamoto, Tohru, Kaneko, Yoshiko, Iijima, Hiroaki, Naito, Takashi, Noguchi, Emiko, Hirota, Tomomitsu, Tamari, Mayumi, Hizawa, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160350/
https://www.ncbi.nlm.nih.gov/pubmed/21774808
http://dx.doi.org/10.1186/1471-2350-12-97