Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib

Objectives Danusertib is a serine/threonine kinase inhibitor of multiple kinases, including aurora-A, B, and C. This explorative study aims to identify possible relationships between single nucleotide polymorphisms in genes coding for drug metabolizing enzymes and transporter proteins and clearance...

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Detalles Bibliográficos
Autores principales: Steeghs, Neeltje, Mathijssen, Ron H. J., Wessels, Judith A. M., de Graan, Anne-Joy, van der Straaten, Tahar, Mariani, Mariangela, Laffranchi, Bernard, Comis, Silvia, de Jonge, Maja J. A., Gelderblom, Hans, Guchelaar, Henk-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Phase I Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160560/
https://www.ncbi.nlm.nih.gov/pubmed/20182906
http://dx.doi.org/10.1007/s10637-010-9405-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160560/
https://www.ncbi.nlm.nih.gov/pubmed/20182906
http://dx.doi.org/10.1007/s10637-010-9405-7

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