The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling fork stability, we find that fork reversal and dormant origin firing due to checkpoint defects are rescued in checkpoint mutant...

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Detalles Bibliográficos
Autores principales: Bermejo, Rodrigo, Capra, Thelma, Jossen, Rachel, Colosio, Arianna, Frattini, Camilla, Carotenuto, Walter, Cocito, Andrea, Doksani, Ylli, Klein, Hannah, Gómez-González, Belén, Aguilera, Andrés, Katou, Yuki, Shirahige, Katsuhiko, Foiani, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160733/
https://www.ncbi.nlm.nih.gov/pubmed/21784245
http://dx.doi.org/10.1016/j.cell.2011.06.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160733/
https://www.ncbi.nlm.nih.gov/pubmed/21784245
http://dx.doi.org/10.1016/j.cell.2011.06.033

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