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Pharmacogenetic Associations of MMP9 and MMP12 Variants with Cardiovascular Disease in Patients with Hypertension
OBJECTIVES: MMP-9 and -12 function in tissue remodeling and may play roles in cardiovascular disease (CVD). We assessed associations of four MMP polymorphisms and three antihypertensive drugs with cardiovascular outcomes. METHODS: Hypertensives (n = 42,418) from a double-blind, randomized, clinical...
Autores principales: | Tanner, Rikki M., Lynch, Amy I., Brophy, Victoria H., Eckfeldt, John H., Davis, Barry R., Ford, Charles E., Boerwinkle, Eric, Arnett, Donna K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160956/ https://www.ncbi.nlm.nih.gov/pubmed/21887284 http://dx.doi.org/10.1371/journal.pone.0023609 |
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