Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target

BACKGROUND: Aberrant Wnt/β-catenin signaling is associated with breast cancer even though genetic mutations in Wnt signaling components are rare. We have previously demonstrated that Rad6B, an ubiquitin conjugating enzyme, stabilizes β-catenin via polyubiqutin modifications that render β-catenin ins...

Descripción completa

Detalles Bibliográficos
Autores principales: Gerard, Brigitte, Tait, Larry, Nangia-Makker, Pratima, Shekhar, Malathy PV
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161051/
https://www.ncbi.nlm.nih.gov/pubmed/21767405
http://dx.doi.org/10.1186/1750-2187-6-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161051/
https://www.ncbi.nlm.nih.gov/pubmed/21767405
http://dx.doi.org/10.1186/1750-2187-6-6

Ejemplares similares