Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions

BACKGROUND: Reactive astrocytes are implicated in the development and maintenance of neuroinflammation in the demyelinating disease multiple sclerosis (MS). The sphingosine kinase 1 (SphK1)/sphingosine1-phosphate (S1P) receptor signaling pathway is involved in modulation of the inflammatory response...

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Detalles Bibliográficos
Autores principales: Fischer, Iris, Alliod, Chantal, Martinier, Nicolas, Newcombe, Jia, Brana, Corinne, Pouly, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161076/
https://www.ncbi.nlm.nih.gov/pubmed/21887342
http://dx.doi.org/10.1371/journal.pone.0023905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161076/
https://www.ncbi.nlm.nih.gov/pubmed/21887342
http://dx.doi.org/10.1371/journal.pone.0023905

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